By Dr. Priyom Bose, Ph.D.Dec 18 2023
Leaky gut, depressive disorders, and metabolites
The intestinal epithelial barrier prevents many toxins and pathogens from entering the lumen. However, certain events like stress can facilitate a leaky gut, which increases the risk of gastrointestinal anomalies and depressive disorders. Other environmental factors like pollution and the consumption of residues in food products like pesticides can also disturb gut permeability and alter the gut microbiome.
Among short-chain fatty acids (SCFAs), butyrate is key to maintaining proper gastrointestinal health. Previous studies have shown that any disruption in the butyrate-mediated gut-blood barrier integrity could lead to depressive disorders.
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